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  2. Aflibercept - Wikipedia

    en.wikipedia.org/wiki/Aflibercept

    In November 2011, the US Food and Drug Administration (FDA) approved aflibercept for the treatment of wet macular degeneration. [ 31 ] [ 32 ] In August 2012, the US FDA approved aflibercept (Zaltrap) for use in combination with 5-fluorouracil , folinic acid and irinotecan to treat adults with metastatic colorectal cancer that is resistant to ...

  3. List of drugs granted breakthrough therapy designation

    en.wikipedia.org/wiki/List_of_drugs_granted...

    Drug Manufacturer Indication Adagrasib: In combination with cetuximab for the treatment of adults with KRAS G12C mutated locally advanced or metastatic colorectal cancer who have been previously treated with fluoropyrimidine-, oxaliplatin-, and irinotecan-based chemotherapy [2] Arimoclomol

  4. Pembrolizumab - Wikipedia

    en.wikipedia.org/wiki/Pembrolizumab

    In June 2020, the US FDA approved a new indication for pembrolizumab as the first-line treatment for people with unresectable or metastatic microsatellite instability-high (MSI‑H) or mismatch repair deficient (dMMR) colorectal cancer. [17] The approval marks the first immunotherapy approved for that population in the US as a first-line ...

  5. US FDA approves Bristol Myers' colorectal cancer therapy

    www.aol.com/news/us-fda-approves-bristol-myers...

    (Reuters) -The U.S. Food and Drug Administration has approved Bristol Myers Squibb's combination therapy for treating colorectal cancer in patients with a specific gene mutation, the health ...

  6. MEK inhibitor - Wikipedia

    en.wikipedia.org/wiki/MEK_inhibitor

    Cobimetinib or XL518, approved by US FDA in Nov 2015 for use in combination with vemurafenib (Zelboraf(R)), for treatment of advanced melanoma with a BRAF V600E or V600K mutation. Selumetinib , had a phase 2 clinical trial for non-small cell lung cancer (NSCLC) which demonstrated an improvement in PFS, [ 5 ] and is now in phase III development ...

  7. List of therapeutic monoclonal antibodies - Wikipedia

    en.wikipedia.org/wiki/List_of_therapeutic...

    This list of over 500 monoclonal antibodies includes approved and investigational drugs as well as drugs that have been withdrawn from market; consequently, the column Use does not necessarily indicate clinical usage. See the list of FDA-approved therapeutic monoclonal antibodies in the monoclonal antibody therapy page.

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