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Reproductive toxicants may adversely affect sexual function, ovarian failure, fertility as well as causing developmental toxicity in the offspring. [2] [3] Lowered effective fertility related to reproductive toxicity relates to both male and female effects alike and is reflected in decreased sperm counts, semen quality and ovarian failure.
Developmental toxicity is any developmental malformation that is caused by the toxicity of a chemical or pathogen. It is the structural or functional alteration, reversible or irreversible, which interferes with homeostasis , normal growth , differentiation , development or behavior.
Ovarian culture is an in-vitro process that allows for the investigation of the development, toxicology and pathology of the ovary. [1] This technique can also be used to study possible applications of fertility treatments e.g. isolating oocytes from primordial ovarian follicles that could be used for fertilisation.
A box model explaining the processes of toxicokinetics and toxicodynamics. While toxicokinetics describes the changes in the concentrations of a toxicant over time due to the uptake, biotransformation, distribution and elimination of toxicants, toxicodynamics involves the interactions of a toxicant with a biological target and the functional or structural alterations in a cell that can ...
Reproductive Toxicology is a peer-reviewed journal published bimonthly by Elsevier which focuses on the effects of toxic substances on the reproductive system. The journal was established in 1987 and is affiliated with the European Teratology Society. According to the Journal Citation Reports, the journal has a 2023 impact factor of 3.3. [1]
Extended One-Generation Reproductive Toxicity Study 451: Carcinogenicity Studies 452: Chronic Toxicity Studies 453: Combined Chronic Toxicity/Carcinogenicity Studies 455: Draft Performance-Based Test Guideline for Stably Transfected Transactivation In Vitro Assays to Detect Estrogen Receptor Agonists and Antagonists 456: H295R Steroidogenesis ...
Suspected female reproductive toxicants (1 C, 1 P) E. Embryotoxicants (3 C, 11 P) F. Fetotoxicants (2 C, 6 P) Pages in category "Female reproductive toxicants"
A chemosterilant is a chemical compound that causes reproductive sterility in an organism. Chemosterilants are particularly useful in controlling the population of species that are known to cause disease, such as insects, or species that are, in general, economically damaging.