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Studies designed to test the teratogenic potential of environmental agents use animal model systems (e.g., rat, mouse, rabbit, dog, and monkey). Early teratologists exposed pregnant animals to environmental agents and observed the fetuses for gross visceral and skeletal abnormalities.
According to the NTP-CERHR the adverse reproductive effects are negligible for exposed men. Yet, one study found a link between altered semen quality and exposure to monobutyl phthalate, a major metabolite of BBP. [21] No research has been done on the teratogenic effects of BBP on humans. However, numerous studies have been conducted with animals.
By far most information on toxicity of dioxin-like chemicals is based on animal studies utilizing TCDD. [4] [8] [35] [36] Almost all organs are affected by high doses of TCDD. In short-term toxicity studies in animals, the typical effects are anorexia and wasting, and even after a huge dose animals die only 1 to 6 weeks after the TCDD ...
Joseph Yanai is a researcher pioneering in studying the reversal of neurobehavioral birth defects in animal models. [1] He serves as a professor and Director of the Ross Laboratory for Studies in Neural Birth Defects at the Department of Medical Neurobiology, The Institute For Medical Research, Israel-Canada (IMRIC) at the Hebrew University-Hadassah Medical School Jerusalem, Israel and was ...
Studies in animals have shown that benznidazole can cross the placenta. [14] Due to its potential for teratogenicity, use of benznidazole in pregnancy is not recommended. [ 9 ]
In a study of 154 women who took the drug in the 1980s, an estimated 20 to 35 percent of fetuses exposed to isotretinoin were born with any number of cardiovascular, craniofacial, thymic, and ...
Studies show that keeping your head at the appropriate height—about 2 inches (or 5 centimeters) off the bed—helps air flow into the lungs and stabilizes your respiratory function. However ...
[23] [24] [25] The FD&C Red No. 2 study was a multi-laboratory collaborative effort between industry, U.S. FDA, and NCTR, while the 2,4,5-T study was a large-scale multireplicated study in various strains/stocks of mice that included replicated test groups, at least four dose levels per replicate, use of multiple stocks/strains of animals to ...