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Its IUPAC name is 6-methoxy-1,2,3,4-tetrahydro-β-carboline, usually abbreviated as 6-MeO-THBC, and its more common name is a combination of "pineal beta-carboline". [2] The biological activity of this molecule is of interest as a potential free radical scavenger, also known as an antioxidant , [ 3 ] and as a monoamine oxidase A inhibitor.
A human prospective cohort study conducted on a sample of 266 people over age 60 demonstrated that treatment with epithalamin, the pineal gland extract upon which epitalon is based, produced a 1.6–1.8-fold reduction in mortality during the following 6 years, a 2.5-fold reduction in mortality when combined with thymalin, and a 4.1-fold ...
Journal of Pineal Research is a peer-reviewed scientific journal covering research on the pineal gland and its hormonal products, chiefly melatonin, in all vertebrate species. Experimental studies on circadian rhythms and sleep are also published by the journal. It is published by John Wiley & Sons and the editor-in-chief is Gianluca Tosini.
The pineal gland (also known as the pineal body [1] or epiphysis cerebri) is a small endocrine gland in the brain of most vertebrates. It produces melatonin, a serotonin-derived hormone, which modulates sleep patterns following the diurnal cycles. [2] The shape of the gland resembles a pine cone, which gives it its name. [3]
The ancient Greeks visualised the pineal gland as a sort of guard (valve), like the pylorus of stomach, that regulate the flow of pneuma (vital spirits) in the brain. Galen of Pergamum in the 2nd century CE was the first to make written record of the gland and argued against the prevailing concept.
The FDA considered whether these food products could continue to be sold with the label "dietary supplements". On 13 January 2010, it issued a Warning Letter to Innovative Beverage, creators of several beverages marketed as drinks, stating that melatonin, while legal as a dietary supplement, was not approved as a food additive . [ 72 ]