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IgA exists in two isotypes, IgA1 and IgA2.They are both heavily glycosylated proteins. [9] While IgA1 predominates in serum (~80%), IgA2 percentages are higher in secretions than in serum (~35% in secretions); [10] the ratio of IgA1 and IgA2 secreting cells varies in the different lymphoid tissues of the human body: [11]
α – IgA, further divided into subclasses IgA1 and IgA2; δ – IgD; γ – IgG, further divided into subclasses IgG1 to IgG4; ε – IgE; μ – IgM; There are also two light chain isotypes κ and λ; however, there is no significant difference in function between the two. Thus an antibody isotype is determined by the constant regions of the ...
Selective immunoglobulin A (IgA) deficiency (SIgAD [1]) is a kind of immunodeficiency, a type of hypogammaglobulinemia.People with this deficiency lack immunoglobulin A (IgA), a type of antibody that protects against infections of the mucous membranes lining the mouth, airways, and digestive tract.
n/a Ensembl ENSG00000211895 n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) Chr 14: 105.7 – 105.71 Mb n/a PubMed search n/a Wikidata View/Edit Human Immunoglobulin heavy constant alpha 1 is a immunoglobulin gene with symbol IGHA1. It encodes a constant (C) segment of Immunoglobulin A heavy chain. Immunoglobulin A is an antibody that plays a critical role in ...
It performs cleavage of human immunoglobulin A subclass 1 (IgA1) molecules in the heavy chain hinge region but does not cleave IgA2. No small molecule substrates are known. No small molecule substrates are known.
IgA nephropathy (IgAN), also known as Berger's disease (/ b ɛər ˈ ʒ eɪ /) (and variations), or synpharyngitic glomerulonephritis, is a disease of the kidney (or nephropathy) and the immune system; specifically it is a form of glomerulonephritis or an inflammation of the glomeruli of the kidney.
Mechanism of class-switch recombination that allows isotype switching in activated B cells. Immunoglobulin class switching, also known as isotype switching, isotypic commutation or class-switch recombination (CSR), is a biological mechanism that changes a B cell's production of immunoglobulin from one type to another, such as from the isotype IgM to the isotype IgG. [1]
IgA-specific metalloendopeptidase (EC 3.4.24.13, immunoglobulin A1 proteinase, IgA protease, IgA1-specific proteinase, IgA1 protease, IgA1 proteinase) is an enzyme. [1] [2] [3] This enzyme catalyses the following chemical reaction: Cleavage of Pro-Thr bond in the hinge region of the heavy chain of human immunoglobulin A