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Another strain, HSV-2 usually causes genital herpes, although the strains are very similar and either can cause herpes in any location. While the disease is commonly passed through normal human contact, it is strongly associated with contact sports — outbreaks in sporting clubs being relatively common. [ 2 ]
Herpes simplex virus 1 and 2 (HSV-1 and HSV-2) are two members of the human Herpesviridae family, a set of viruses that produce viral infections in the majority of humans. [1] [2] Both HSV-1 and HSV-2 are very common and contagious. They can be spread when an infected person begins shedding the virus.
For Herpes simplex virus 2, subclinical shedding may account for most of the transmission. [7] Studies on discordant partners (one infected, one not) show that the transmission rate is approximately 5 per 10,000 sexual contacts. [9] Atypical symptoms are often attributed to other causes, such as a yeast infection. [5] [10]
Genocea Biosciences has developed GEN-003, a first-in-class protein subunit T cell-enabled therapeutic vaccine, or immunotherapy, designed to reduce the duration and severity of clinical symptoms associated with moderate-to-severe HSV-2, and to control transmission of the infection.
The risk of transmission to the newborn is 30–57% in cases where the mother acquired a primary infection in the third trimester of pregnancy. Risk of transmission by a mother with existing antibodies for both HSV-1 and HSV-2 has a much lower (1–3%) transmission rate.
Furthermore, long-term treatment of genital herpes with valacyclovir daily has shown to decrease the rates of transmission. [25] It is important for patients to continue suppressive therapy in conjunction to consistent condom use and sexual abstinence during recurrent episodes to decrease transmission as well. [20]