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The IOP is higher during sleep. Efficacy of timolol in lowering IOP during the sleep period may be limited. [16] [17] [18] It is a 5–10× more potent beta blocker than propranolol. Timolol is light-sensitive; it is usually preserved with 0.01% benzalkonium chloride (BAC), but also comes BAC-free.
It is used as the hydrochloride, which melts at 209 to 211 °C (408 to 412 °F) and is soluble in water and methanol and slightly soluble in ethanol. [ 2 ] References
K ow, being a type of partition coefficient, serves as a measure of the relationship between lipophilicity (fat solubility) and hydrophilicity (water solubility) of a substance. The value is greater than one if a substance is more soluble in fat-like solvents such as n-octanol, and less than one if it is more soluble in water. [citation needed]
Betaxolol is most commonly ingested orally alone or with other medications for the management of essential hypertension. [4] It is a cardioselective beta blocker, targeting beta-1 adrenergic receptors found in the cardiac muscle.
Brimonidine is an α 2 adrenergic agonist. [4]Peripheral α 2 agonist activity results in vasoconstriction of blood vessels (as opposed to central α 2 agonist activity that decreases sympathetic tone, as can be seen by the medication clonidine).
Depending on the solute and range of concentration, an aqueous electrolyte solution can have either a larger or smaller viscosity compared with pure water at the same temperature and pressure. For instance, a 20% saline ( sodium chloride ) solution has viscosity over 1.5 times that of pure water, whereas a 20% potassium iodide solution has ...
Sapphire is a notable example of variable thermal conductivity based on orientation and temperature, with 35 W/(m⋅K) along the c axis and 32 W/(m⋅K) along the a axis. [26] Wood generally conducts better along the grain than across it.
The difference of temperatures between the freezing- and boiling-points of water under standard atmospheric pressure shall be called 100 degrees. (The same increment as the Celsius scale) Thomson's best estimates at the time were that the temperature of freezing water was 273.7 K and the temperature of boiling water was 373.7 K. [33]