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Besides their potential medical use, modafinil analogues, including adrafinil, flmodafinil, fladrafinil, and modafiendz, are also sold online as substances that are believed to improve cognitive functions such as memory and focus (nootropics or "cognitive enhancers"). [1] [9] [10] [11]
A position that adrafinil is an unapproved drug was indicated in a warning letter [1] by the FDA in 2019: “Your [particular] products [subject to this warning] [including] Adrafinil…are not generally recognized as safe and effective for the above referenced uses and, therefore, these products are 'new drugs' under section 201(p) of the Act.
Armodafinil acts as a selective atypical dopamine reuptake inhibitor (DRI) and hence as an indirect dopamine receptor agonist. [1] [5] [11] However, other mechanisms might also be involved in its effects. [1] [5] [11] Chemically, armodafinil is the enantiopure (R)-(–)-enantiomer of the racemic mixture modafinil (brand name Provigil).
Regular physical activity can help accelerate weight loss, improve metabolism and enhance the benefits of weight loss pills. Aim for 150 minutes per week (or about a half-hour five days a week).
The wakefulness-promoting agent modafinil and its analogues (e.g., adrafinil, armodafinil) have been approved to treat narcolepsy and shift work sleep disorder. [6] These act as weak DRIs, [7] but this effect does not correlate with wakefulness-promoting effects, suggesting the effect is too weak to be of clinical significance.
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