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HIV is a retrovirus that primarily infects components of the human immune system such as CD4 + T cells, macrophages and dendritic cells. It directly and indirectly destroys CD4 + T cells. [88] HIV is a member of the genus Lentivirus, [89] part of the family Retroviridae. [90] Lentiviruses share many morphological and biological characteristics.
The CDC expanded the definition of HIV to include symptoms experienced by people of color and women in HIV trials and treatment recurrent pneumonia, pulmonary tuberculosis, stage III cervical cancer and recurrent vaginal candidiasis (yeast infections) [21] [34] The International Community of Women Living with HIV/AIDS (ICW) was founded. [11] 1993
Two types of HIV have been characterized: HIV-1 and HIV-2. HIV-1 is the virus that was initially discovered and termed both lymphadenopathy associated virus (LAV) and human T-lymphotropic virus 3 (HTLV-III). HIV-1 is more virulent and more infective than HIV-2, [20] and is the cause of the majority of HIV infections globally. The lower ...
HIV antibody tests are highly sensitive, meaning they react preferentially with HIV antibodies, but not all positive or inconclusive HIV ELISA tests mean the person is infected by HIV. Risk history, and clinical judgement should be included in the assessment, and a confirmation test (western blot) should be administered.
It progresses rapidly, usually causing death within months of diagnosis. [25] HIV-associated dementia (HAD) is a metabolic encephalopathy induced by HIV infection and fueled by immune activation of HIV-infected brain macrophages and microglia. These cells are productively infected by HIV and secrete neurotoxins of both host and viral origin. [26]
In honor of National Black HIV/AIDS Awareness Day, Marvelyn Brown shares her story on becoming HIV positive and what she wants people to know about the virus.
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