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Endochondral ossification[1][2] is one of the two essential pathways by which bone tissue is produced during fetal development of the mammalian skeletal system, the other pathway being intramembranous ossification. Both endochondral and intramembranous processes initiate from a precursor mesenchymal tissue, but their transformations into bone ...
Transmission electron micrograph of a mesenchymal stem cell that is displaying typical ultrastructural characteristics. Unlike endochondral ossification, which is the other process by which bone tissue is created during fetal development, cartilage is not present during intramembranous ossification.
Ossification. Bone is broken down by osteoclasts, and rebuilt by osteoblasts, both of which communicate through cytokine (TGF-β, IGF) signalling. Ossification (also called osteogenesis or bone mineralization) in bone remodeling is the process of laying down new bone material by cells named osteoblasts.
The bones that form the base and facial regions of the skull develop through the process of endochondral ossification. In this process, mesenchyme accumulates and differentiates into hyaline cartilage, which forms a model of the future bone. The hyaline cartilage model is then gradually, over a period of many years, displaced by bone.
Chondrogenesis is the biological process through which cartilage tissue is formed and developed. This intricate and tightly regulated cellular differentiation pathway plays a crucial role in skeletal development, as cartilage serves as a fundamental component of the embryonic skeleton. The term "chondrogenesis" is derived from the Greek words ...
Primary endochondral ossification begins with the formation of a chondrocyte template. Afterwards, chondrocytes undergo hypertrophy beginning from the mid- diaphysis , eventually extending to the epiphyseal poles, vasculature invades the forming bone transporting mesenchymal stromal cells and hypertrophic cells undergo apoptosis.
Endochondral ossification is the process of forming bone from cartilage and this is the usual method. This form of bone development is the more complex form: it follows the formation of a first skeleton of cartilage made by chondrocytes , which is then removed and replaced by bone, made by osteoblasts.
Mesenchymal (mesoderm origin) ... Endochondral ossification is the process by which most vertebrate axial skeletons form into hardened bones from cartilage.