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ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as the breast cancer resistance protein ( BCRP ), this protein functions as a xenobiotic transporter which may play a role in multi-drug resistance to chemotherapeutic ...
OGT stabilization of EZH2 in various breast cancer cell lines has been found to inhibit expression of tumor suppressor genes. [79] In hepatocellular carcinoma models, O -GlcNAc is associated with activating phosphorylation of HDAC1, which in turn regulates expression of the cell cycle regulator p21 Waf1/Cip1 and cell motility regulator E-cadherin .
Human BCAR1 genome location and BCAR1 gene details page in the UCSC Genome Browser. Overview of all the structural information available in the PDB for UniProt: P56945 (Human Breast cancer anti-estrogen resistance protein 1) at the PDBe-KB.
If a patient with ER+ breast cancer develops endocrine resistance, the endocrine therapy used to treat the cancer will no longer be effective. Approximately 30-50% of ER+ breast cancer patients will relapse as a result of endocrine resistance, proving it to be a predominant challenge in the treatment of ER+ breast cancer patients. [19]
In general, β-1,3 linkages are created by 1,3-beta-glucan synthase, and β-1,4 linkages are created by cellulose synthase. The process leading to β-1,6 linkages is poorly understood: although genes important in the process have been identified, not much is known about what each of them do. [9]
There are two general causes of antineoplastic therapy failure: [2] Inherent resistance, such as genetic characteristics, giving cancer cells their resistance from the beginning, which is rooted in the concept of cancer cell heterogeneity and acquired resistance after drug exposure. [2]