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Nilotinib is a selective Bcr-Abl kinase inhibitor. [13] [18] Nilotinib is 10-30 fold more potent than imatinib in inhibiting activity of the Bcr-Abl tyrosine kinase and proliferation of Bcr-Abl expressing cells. [12] [18] [20] [21] The drug effectively inhibits the auto phosphorylation of Bcr-Abl on Tyr-177 that is involved in CML pathogenesis ...
The symbol BCR is derived from breakpoint cluster region, a gene which encodes a protein that acts as a guanine nucleotide exchange factor for Rho GTPase proteins. [7] Translocation results in an oncogenic BCR-ABL1 gene fusion that can be found on the shorter derivative chromosome 22. This gene encodes for a BCR-ABL1 fusion protein.
BCR Chișinău is a Moldavian bank that provides services to individual and business customers and is headquartered in Chișinău. [ 2 ] It was a subsidiary of Romanian Banca Comercială Română , member of Erste Group until January 2024 when the Moldovian subsidiary was acquired by Moldovian Victoriabank .
BCR may refer to: Companies. Brockmore Classic Replicas, British manufacturer; Organisations. Banca Comercială Român ă, a ...
A benefit–cost ratio [1] (BCR) is an indicator, used in cost–benefit analysis, that attempts to summarize the overall value for money of a project or proposal. A BCR is the ratio of the benefits of a project or proposal, expressed in monetary terms, relative to its costs, also expressed in monetary terms.
William Jefferson Clinton (né Blythe; born August 19, 1946) is an American politician and lawyer who served as the 42nd president of the United States from 1993 to 2001. A member of the Democratic Party, he previously served as the attorney general of Arkansas from 1977 to 1979 and as the governor of Arkansas from 1979 to 1981, and again from 1983 to 1992.