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Collective cell migration describes the movements of group of cells and the emergence of collective behavior from cell-environment interactions and cell-cell communication. Collective cell migration is an essential process in the lives of multicellular organisms , e.g. embryonic development , wound healing and cancer spreading ( metastasis ). [ 1 ]
Cell migration is a central process in the development and maintenance of multicellular organisms.Tissue formation during embryonic development, wound healing and immune responses all require the orchestrated movement of cells in particular directions to specific locations.
This movement into tissues is called extravasation. It requires successive forming and breaking of cell-cell interactions between the leukocytes and the endothelial cells that line blood vessels. These cell-cell interactions are mediated mainly by a group of Cell Adhesion Molecules (CAMs) called selectins. [1]
Amoeboid movement is the most typical mode of locomotion in adherent eukaryotic cells. [1] It is a crawling-like type of movement accomplished by protrusion of cytoplasm of the cell involving the formation of pseudopodia ("false-feet") and posterior uropods. One or more pseudopodia may be produced at a time depending on the organism, but all ...
In forward movement, the long axis of the cell, the flagellar bundle and the direction of movement are aligned, and propulsion is similar to the propulsion of a freely swimming cell. In a reversal, the flagellar bundle loosens, with the filaments in the bundle changing from their "normal form" (left-handed helices) into a "curly" form of right ...
Schematic of cell adhesion. Cell adhesion is the process by which cells interact and attach to neighbouring cells through specialised molecules of the cell surface. This process can occur either through direct contact between cell surfaces such as cell junctions or indirect interaction, where cells attach to surrounding extracellular matrix, a gel-like structure containing molecules released ...
Interaction between organisms. the processes by which an organism has an observable effect on another organism of the same or different species. Also: cellular differentiation, fermentation, fertilisation, germination, tropism, hybridisation, metamorphosis, morphogenesis, photosynthesis, transpiration.
Contact inhibition is a regulatory mechanism that functions to keep cells growing into a layer one cell thick (a monolayer). If a cell has plenty of available substrate space, it replicates rapidly and moves freely. This process continues until the cells occupy the entire substratum. At this point, normal cells will stop replicating.