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This list of over 500 monoclonal antibodies includes approved and investigational drugs as well as drugs that have been withdrawn from market; consequently, the column Use does not necessarily indicate clinical usage. See the list of FDA-approved therapeutic monoclonal antibodies in the monoclonal antibody therapy page.
The first immunology antibody–drug conjugate (iADC), ABBV-3373, [18] showed an improvement in disease activity in a Phase 2a study of patients with rheumatoid arthritis [19] and a study with the second iADC, ABBV-154 [20] [21] to evaluate adverse events and change in disease activity in participants treated with subcutaneous injection of ABBV ...
These conjugates are used in immunotherapy [citation needed] and to develop monoclonal antibody therapy as a targeted form of chemotherapy [2] when they are often known as antibody-drug conjugates. When the conjugates include a radioisotope see radioimmunotherapy. When the conjugates include a toxin see immunotoxin.
Immune stimulating antibody conjugates work by activating dendritic cells within the tumor, [3] and are capable of being delivered systemically. [4] With some patients being resistant to checkpoint inhibitors, immune stimulating antibody conjugates may be able to harness an immune response generated through the stimulation of toll-like ...
Pages in category "Antibody-drug conjugates" The following 57 pages are in this category, out of 57 total. This list may not reflect recent changes. ...
Researchers at Boston’s Dana-Farber Cancer Institute are working on a drug that takes one of the virus’s most dangerous traits — its talent for mutation — and turns it back on itself.
On 21 November 2020, the U.S. Food and Drug Administration (FDA) issued an emergency use authorization (EUA) for casirivimab and imdevimab to be administered together for the treatment of mild to moderate [COVID‑19] in people twelve years of age or older weighing at least 40 kilograms (88 lb) with positive results of direct SARS-CoV-2 viral ...
Being adapted from the broad and successful class of Antibody-Drug conjugates, antibodies and antibody analogues are more and more used in research in order to overcome hurdles related to delivery and internalisation of ON therapeutics. By exploiting bioconjugation methodology several conjugates have been obtained.