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All available studies examining the correlation between the target drug and its biological responses will be reviewed. The selection criteria for the critical responses for assessment is that the dose required to produce that particular response is the lowest. [1] The precursor of a biological effect can also be the response for assessment. [1]
Inotuzumab ozogamicin is used to treat relapsed or refractory B-cell precursor acute lymphoblastic leukemia. [4] [5]In March 2024, the FDA approved inotuzumab ozogamicin for the treatment of children aged one year and older with relapsed or refractory CD22-positive B-cell precursor acute lymphoblastic leukemia.
The United States Environmental Protection Agency defines NOAEL as 'an exposure level at which there are no statistically or biologically significant increases in the frequency or severity of adverse effects between the exposed population and its appropriate control; some effects may be produced at this level, but they are not considered as adverse, or as precursors to adverse effects. [5]
Hydroxytyrosol is considered safe as a novel food for human consumption, with a no-observed-adverse-effect level of 50 mg/kg body weight per day, as evaluated by the European Food Safety Authority (EFSA). [10] In the United States, hydroxytyrosol is considered to be a safe ingredient in processed foods at levels of 5 mg per serving. [11]
X-ray absorption (left) and differential phase-contrast (right) image of an in-ear headphone obtained with a grating interferometer at 60kVp. Phase-contrast X-ray imaging or phase-sensitive X-ray imaging is a general term for different technical methods that use information concerning changes in the phase of an X-ray beam that passes through an object in order to create its images.
Iohexol, sold under the trade name Iodaque among others, is a contrast agent used for X-ray imaging. [4] This includes when visualizing arteries, veins, ventricles of the brain, the urinary system, and joints, as well as during computed tomography (CT scan). [4] It is given by mouth, injection into a vein, or into a body cavity. [5]
Ray tracing is a technique that can generate near photo-realistic computer images. A wide range of free software and commercial software is available for producing these images. This article lists notable ray-tracing software.
High energy X-ray imaging technology (HEXITEC) is a family of spectroscopic, single photon counting, pixel detectors developed for high energy X-ray and gamma ray spectroscopy applications. [1] [2] The HEXITEC consortium was formed in 2006 funded by the Engineering and Physical Sciences Research Council, UK.