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Glucagon-like peptide-1 (GLP-1) is a 30- or 31-amino-acid-long peptide hormone deriving from tissue-specific posttranslational processing of the proglucagon peptide. It is produced and secreted by intestinal enteroendocrine L-cells and certain neurons within the nucleus of the solitary tract in the brainstem upon food consumption.
In December 2024, Novo Nordisk announced the results of REDEFINE 1, one of their series of Phase III trials, testing weekly cagrilintide 2.4 mg and semaglutide 2.4 mg individually and together versus placebo in obese or overweight subjects with one or more comorbidities. [7]
GLP1 poly-agonist peptides [1] are a class of drugs that activate multiple peptide hormone receptors including the glucagon-like peptide-1 (GLP-1) receptor. These drugs are developed for the same indications as GLP-1 receptor agonists —especially obesity, type 2 diabetes, and non-alcoholic fatty liver disease.
Semaglutide works by mimicking a protein in your body called glucagon-like peptide 1, a.k.a. GLP-1—the same GLP-1 that keeps coming up all over the place lately, says Kunal Shah, MD, an ...
[23] [24] [25] It is a peptide similar to the hormone glucagon-like peptide-1 (GLP-1), modified with a side chain. [ 26 ] [ 27 ] It can be administered by subcutaneous injection or taken orally . [ 14 ] [ 15 ] [ 16 ] [ 28 ] It is sold by Novo Nordisk under the brand names Ozempic [ 14 ] and Rybelsus [ 15 ] for diabetes, and under the brand name ...
You can’t go far lately without seeing news and social media coverage of GLP-1 (glucagon-like peptide-1) receptor ... let’s go over the basics of this drug. ... an estimated 20 to 40 percent ...
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