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Piperidine is widely used to convert ketones to enamines. [23] Enamines derived from piperidine are substrates in the Stork enamine alkylation reaction. [24] Upon treatment with calcium hypochlorite, piperidine converts to N-chloropiperidine, a chloramine with the formula C 5 H 10 NCl.
Piperidine, a cyclic six-membered amine that results from hydrolysis of piperine; Piperic acid, the carboxylic acid also derived from hydrolysis of piperine; Capsaicin, the active piquant chemical in chili peppers; Allyl isothiocyanate, the active piquant chemical in mustard, radishes, horseradish, and wasabi
2-Benzylpiperidine is a stimulant drug of the aryl piperidine family. It is similar in structure to certain other stimulants such as methylphenidate and desoxypipradrol.However, it is far less potent as a monoamine reuptake inhibitor in comparison.
[35] [36] The suggestion by Körner and Dewar was later confirmed in an experiment where pyridine was reduced to piperidine with sodium in ethanol. [37] [38] In 1876, William Ramsay combined acetylene and hydrogen cyanide into pyridine in a red-hot iron-tube furnace. [39] This was the first synthesis of a heteroaromatic compound. [24] [40]
N,O-Dimethyl-4β-(2-naphthyl)piperidine-3β-carboxylate (DMNPC) is a piperidine based stimulant drug which is synthesised from arecoline. It is similar to nocaine in chemical structure, and has two and a half times more activity than cocaine as a dopamine reuptake inhibitor .
4-Benzylpiperidine acts as a monoamine releasing agent with 20- to 48-fold selectivity for releasing dopamine versus serotonin.It is most efficacious as a releaser of norepinephrine, with an EC 50 of 109 nM (DA), 41.4 nM (NE), and 5,246 nM ().
Piperidine, the parent compound of piperidine alkaloids Piperidine alkaloids are naturally occurring chemical compounds from the group of alkaloids , which are chemically derived from piperidine . Alkaloids with a piperidine building block are widespread and are usually further subdivided according to their occurrence and biogenetic origin.
4-Amino-2,2,6,6-tetramethyl-4-piperidine is an organic compound with the formula H 2 NCH(CH 2 CMe 2) 2 NH (where Me = CH 3). Classified as a diamine , it is a colorless oily liquid. The compound is an intermediate in the preparation of Bobbitt's salt , an oxidant used in organic synthesis.