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Cilansetron is an experimental drug that is a 5-HT 3 antagonist under development by Solvay Pharmaceuticals. [ 1 ] [ 2 ] [ 3 ] 5-HT 3 receptors are responsible for causing many things from nausea to excess bowel movements .
Alosetron, sold under the brand name Lotronex among others, is a 5-HT 3 antagonist used for the management of severe diarrhea-predominant irritable bowel syndrome (IBS) in females only. It was patented in 1987 and approved for medical use in 2002. [ 2 ]
Alosetron and cilansetron—the latter was developed by Solvay but never approved by the FDA —are not antiemetics; instead, they are indicated in the treatment of a subset of irritable bowel syndrome where diarrhea is the dominant symptom.
Alosetron; Cilansetron; Also, the antidepressant mirtazapine acts as a 5-HT 3 antagonist. Non-selective 5-HT antagonists. Although some non-selective serotonin ...
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Palonosetron does not relevantly inhibit or induce cytochrome P450 liver enzymes. There are case reports about serotonin syndrome when the drug is combined with serotonergic substances, such as selective serotonin reuptake inhibitors (SSRIs) and serotonin–norepinephrine reuptake inhibitors (SNRIs), two common types of antidepressants.
Methylscopolamine or methscopolamine, usually provided as the bromide or nitrate salt, is an oral medication used along with other medications to treat peptic ulcers by reducing stomach acid secretion. [1]
Ramosetron is a serotonin 5-HT 3 receptor antagonist for the treatment of nausea and vomiting. [1] Ramosetron is also indicated for a treatment of "diarrhea-predominant irritable bowel syndrome in male and women". [2]