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2 Example. 3 References. Toggle the table of contents. ... As the name suggests, a non-nucleophilic base is a sterically hindered organic base that is a poor ...
Pages in category "Non-nucleophilic bases" The following 26 pages are in this category, out of 26 total. This list may not reflect recent changes. ...
It is used as a non-nucleophilic base, being comparable to LiHMDS in terms of steric hindrance. Synthesis It is ...
Lithium diisopropylamide (commonly abbreviated LDA) is a chemical compound with the molecular formula LiN(CH(CH 3) 2) 2.It is used as a strong base and has been widely utilized due to its good solubility in non-polar organic solvents and non-nucleophilic nature.
N,N-Diisopropylethylamine, or Hünig's base, is an organic compound that is a tertiary amine. It is named after the German chemist Siegfried Hünig . It is used in organic chemistry as a non-nucleophilic base. It is commonly abbreviated as DIPEA, DIEA, or i-Pr 2 NEt.
It is a strong, non-nucleophilic base. It is flammable and moisture sensitive. It is sometimes written in the chemical literature as sodium t-butoxide. It is similar in reactivity to the more common potassium tert-butoxide. The compound can be produced by treating tert-butyl alcohol with sodium hydride. [3]
LiHMDS is often used in organic chemistry as a strong non-nucleophilic base. [3] Its conjugate acid has a pK a of ~26, [4] making it is less basic than other lithium bases, such as LDA (pK a of conjugate acid ~36). It is relatively more sterically hindered and hence less nucleophilic than other lithium bases.
Tetramethylguanidine is mainly used as a strong, non-nucleophilic base for alkylations, often as a substitute for the more expensive DBU and DBN. [3] Since it is highly water-soluble, it is easily removed from mixtures in organic solvents. It is also used as a base-catalyst in the production of polyurethane. [4]