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The severity of these symptoms are determined by the period of hypothyroidism and the degree of deficiency of thyroid hormones. [10] It may also include macroglossia. [11] EMG is either normal or may show myopathic low amplitude and short duration motor unit action potentials (MUAPS). [12] The enzymes creatine kinase is elevated usually.
Hypothyroidism is the most frequent endocrine disorder. [43] Worldwide about one billion people are estimated to be iodine deficient; however, it is unknown how often this results in hypothyroidism. [11] In large population-based studies in Western countries with sufficient dietary iodine, 0.3–0.4% of the population have overt hypothyroidism.
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It is the most common cause of hypothyroidism in developed countries. [10] It typically begins between the ages of 30 and 50. [3] [4] Rates of the disease have increased. [9] It was first described by the Japanese physician Hakaru Hashimoto in 1912. [11] Studies in 1956 discovered that it was an autoimmune disorder. [12]
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Thyroid diseases are highly prevalent worldwide, [10] [11] [12] and treatment varies based on the disorder. Levothyroxine is the mainstay of treatment for people with hypothyroidism, [13] while people with hyperthyroidism caused by Graves' disease can be managed with iodine therapy, antithyroid medication, or surgical removal of the thyroid ...
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Iodine deficiency causes gradual enlargement of the thyroid gland, referred to as a goiter. Poor length growth is apparent as early as the first year of life. Adult stature without treatment ranges from 100 to 160 cm (3 ft 3 in to 5 ft 3 in), depending on severity, sex, and other genetic factors.