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The collecting duct system of the kidney consists of a series of tubules and ducts that physically connect nephrons to a minor calyx or directly to the renal pelvis.The collecting duct participates in electrolyte and fluid balance through reabsorption and excretion, processes regulated by the hormones aldosterone and vasopressin (antidiuretic hormone).
The medulla in mammals is divided into outer and inner regions. The outer region consists of short loops of Henle and collecting ducts, while the inner region consists of long loops and collecting ducts. [78] The outer region is also subdivided into outer [79] (lying directly under the cortex) [80] and inner stripes. [79]
The medullary interstitium is the tissue surrounding the loop of Henle in the medulla. It functions in renal water reabsorption by building up a high hypertonicity, which draws water out of the thin descending limb of the loop of Henle and the collecting duct system.
The collecting duct system begins in the renal cortex and extends deep into the medulla. As the urine travels down the collecting duct system, it passes by the medullary interstitium which has a high sodium concentration as a result of the loop of Henle's countercurrent multiplier system. [1]: 67
Urea transporter A1 transports urea across the apical membrane into the intracellular space of luminal cells in the inner medullary collecting duct of the kidneys. UT-1 is activated by ADH, but is a passive transporter. It reabsorbs up to 70% of the original filtered load of urea. [5]
This is followed by a renal tubule that passes from the cortex deep into the medullary pyramids. Part of the renal cortex, a medullary ray is a collection of renal tubules that drain into a single collecting duct. [citation needed] Renal histology is the study of the microscopic structure of the kidney.
Collecting duct system; S1 S2 S3 descending limb: thin ascending limb: thick ascending limb: connecting tubule: initial collecting tubule cortical collecting ducts medullary collecting ducts reabsorption (% compared to filtered amount) 50 [1] 50 secretion (% compared to filtered amount) 50 [1] reabsorption (mmoles/day) Concentration: electrical ...
The saltier the medulla, the more water can be reabsorbed from the pre-urine in collecting duct; before it becomes urine. [5] Aquaporin-2 (AQ2) sits in collecting duct and is selectively inserted into cell membranes, according to the body's needs, to reabsorb water to create that balance. [6]