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Cutaneous lymphoid hyperplasia refers to a groups of benign cutaneous disorders characterized by collections of lymphocytes, macrophages, and dendritic cells in the skin. [ 2 ] : 725 Conditions included in this groups are: [ 2 ] : 725
Lymphoid hyperplasia is the rapid proliferation of normal lymphocytic cells that resemble lymph tissue which may occur with bacterial or viral infections. [1] The growth is termed hyperplasia which may result in enlargement of various tissue including an organ, or cause a cutaneous lesion .
The lymphocytes are primarily B cells (e.g., express CD20 and CD10 markers) with rare T cells evident only in the background. [32] The B cells are derived mostly from germinal center B cells, contain EBV in latency I phase, and express high levels of EBNA1 and EBER viral products. Some cases also express other EBNA and the LMP2A products. [1]
Lymphoproliferative disorders (LPDs) refer to a specific class of diagnoses, comprising a group of several conditions, in which lymphocytes are produced in excessive quantities. These disorders primarily present in patients who have a compromised immune system .
In immunology, immunoproliferative disorders are disorders of the immune system that are characterized by the abnormal proliferation of the primary cells of the immune system, which includes B cells, T cells and natural killer (NK) cells, or by the excessive production of immunoglobulins (also known as antibodies).
Cutaneous lymphoid hyperplasia with bandlike and perivascular patterns; Cutaneous lymphoid hyperplasia with nodular pattern (nodular pattern of cutaneous lymphoid hyperplasia) Diffuse large B-cell lymphoma (primary cutaneous large B-cell lymphoma) Granulocytic sarcoma (chloroma, myeloid sarcoma) Granulomatous slack skin; Hairy-cell leukemia ...
Cutaneous B-cell lymphomas (CBCL), more recently termed Primary cutaneous B-cell lymphomas and lymphoproliferative disorders (PCBCLPD), are a group of disorders that typically present as skin lesions consisting of proliferating B-cells. B-cells are a type of lymphocyte involved in regulating immune responses.
Nodular pattern of cutaneous lymphoid hyperplasia; Non-mycosis fungoides CD30− cutaneous large T-cell lymphoma; Non-mycosis fungoides CD30− pleomorphic small/medium sized cutaneous T-cell lymphoma; Non-mycosis fungoides CD30- pleomorphic small/medium sized cutaneous T-cell lymphoma; Nonspecific cutaneous conditions associated with leukemia