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cIAP1 (also named BIRC2) is the abbreviation for a human protein, cellular inhibitor of apoptosis protein-1. It belongs to the IAP family of proteins and therefore contains at least one BIR (baculoviral IAP repeat) domain.
p21 Cip1 (alternatively p21 Waf1), also known as cyclin-dependent kinase inhibitor 1 or CDK-interacting protein 1, is a cyclin-dependent kinase inhibitor (CKI) that is capable of inhibiting all cyclin/CDK complexes, [5] though is primarily associated with inhibition of CDK2.
Cip1-interacting zinc finger protein is a protein that in humans is encoded by the CIZ1 gene. [5] [6] Function. The protein encoded by this gene is a zinc finger DNA ...
Solute carrier family 12 member 9 (SLC12A9), also known as cation-chloride cotransporter 6 (CCC6) or cation-chloride cotransporter-interacting protein 1 (CIP1), is a protein that in humans is encoded by the SLC12A9 gene.
It has been shown that the inhibition of cyclin D (cyclin D1 and 2, in particular) could result from the induction of WAF1/CIP1/p21 protein by PDT. By inhibiting cyclin D, this induction also inhibits Ckd2 and 6. All these processes combined lead to an arrest of the cell in G0/G1 stage. [5]
Akt both indirectly and directly regulates cyclin-dependent kinase (CDK) inhibitors p21 Cip1 and p27 Kip1, allowing cell cycle progression. Akt phosphorylates p27 kip1 at Thr157, preventing its nuclear import. [33] In addition, Akt phosphorylates Thr145 and Ser146 of p21 Cip1, preventing PCNA binding and decreasing stability. [34]
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