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Azithromycin causes QT prolongation that may cause life-threatening arrhythmias such as torsades de pointes. [11] No harm has been found with its use during pregnancy. [10] Its safety during breastfeeding is not confirmed, but it is likely safe. [12] Azithromycin is an azalide, a type of macrolide antibiotic. [10]
However, not all of them are safe to use during pregnancy. One of the components of bismuth subsalicylate is salicylate, which is a component that crosses the placenta. Due to this, there is an increased risk for intrauterine growth retardation, fetal hemorrhage, and maternal hemorrhage within organogenesis and in the second/third trimester. [ 12 ]
Potential toxicity to mother and fetus during pregnancy; Enamel hypoplasia (staining of teeth; potentially permanent) Transient depression of bone growth; Inhibits the binding of aminoacyl-tRNA to the mRNA-ribosome complex. They do so mainly by binding to the 30S ribosomal subunit in the mRNA translation complex. But Tetracycline cannot be ...
The β-lactam core structures. (A) A penam.(B) A carbapenam.(C) An oxapenam.(D) A penem.(E) A carbapenem.(F) A monobactam.(G) A cephem.(H) A carbacephem.(I) An oxacephem. This is a list of common β-lactam antibiotics—both administered drugs and those not in clinical use—organized by structural class.
β-Lactam antibiotics are indicated for the prevention and treatment of bacterial infections caused by susceptible organisms. At first, β-lactam antibiotics were mainly active only against gram-positive bacteria, yet the recent development of broad-spectrum β-lactam antibiotics active against various gram-negative organisms has increased their usefulness.
Pfizer reported its vaccine for children 5 to 11 was safe and effective in late September and filed for emergency use authorization on Oct. 7. That EUA was granted Nov. 2.
Erythromycin also appears to be safe to use during pregnancy. [2] While generally regarded as safe during breastfeeding, its use by the mother during the first two weeks of life may increase the risk of pyloric stenosis in the baby. [5] [6] This risk also applies if taken directly by the baby during this age. [7]
Narrow-spectrum antibiotics have low propensity to induce bacterial resistance and are less likely to disrupt the microbiome (normal microflora). [3] On the other hand, indiscriminate use of broad-spectrum antibiotics may not only induce the development of bacterial resistance and promote the emergency of multidrug-resistant organisms, but also cause off-target effects due to dysbiosis.