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In general, flux in biology relates to movement of a substance between compartments. There are several cases where the concept of flux is important. The movement of molecules across a membrane: in this case, flux is defined by the rate of diffusion or transport of a substance across a permeable membrane.
It is easiest to describe the flux of metabolites through a pathway by considering the reaction steps individually. The flux of the metabolites through each reaction (J) is the rate of the forward reaction (V f), less that of the reverse reaction (V r): [2]
Fluxes may have more than one function at a time. They are used in both extractive metallurgy and metal joining. Some of the earliest known fluxes were sodium carbonate, potash, charcoal, coke, borax, [1] lime, [2] lead sulfide [3] and certain minerals containing phosphorus. Iron ore was also used as a flux in the smelting of copper.
In the latter case flux can readily be integrated over a surface. By contrast, according to the electromagnetism definition, flux is the integral over a surface; it makes no sense to integrate a second-definition flux for one would be integrating over a surface twice. Thus, Maxwell's quote only makes sense if "flux" is being used according to ...
Anatomy is a branch of natural science that deals with the structural organization of living things. It is an old science, having its beginnings in prehistoric times. [ 3 ] Anatomy is inherently tied to developmental biology , embryology , comparative anatomy , evolutionary biology , and phylogeny , [ 4 ] as these are the processes by which ...
Metabolic flux analysis (MFA) is an experimental fluxomics technique used to examine production and consumption rates of metabolites in a biological system. At an intracellular level, it allows for the quantification of metabolic fluxes, thereby elucidating the central metabolism of the cell. [1]
In physical terms, the divergence of a vector field is the extent to which the vector field flux behaves like a source or a sink at a given point. It is a local measure of its "outgoingness" – the extent to which there are more of the field vectors exiting from an infinitesimal region of space than entering it.
The significance of fluxomics is that metabolic fluxes determine the cellular phenotype. [3] It has the added advantage of being based on the metabolome which has fewer components than the genome or proteome. [4] Fluxomics falls within the field of systems biology which developed with the appearance of high throughput technologies. [5]