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PET scanning is also used for diagnosis of brain disease, most notably because brain tumors, strokes, and neurondegenerative diseases (such as Alzheimer's disease and Parkinson's disease) all cause great changes in brain metabolism, which in turn causes detectable changes in PET scans. PET is probably most useful in early cases of certain ...
Whole-body PET scan using 18 F-FDG (fluorodeoxyglucose). The normal brain and kidneys are labeled, and radioactive urine from breakdown of the FDG is seen in the bladder. In addition, a large metastatic tumor mass from colon cancer is seen in the liver. PET scanning with the radiotracer [18 F]fluorodeoxyglucose (FDG) is widely used in clinical ...
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In PET scans, imaging does not rely on intrinsic biological processes, but relies on a foreign substance injected into the bloodstream traveling to the brain. Patients are injected with radioisotopes that are metabolized in the brain and emit positrons to produce a visualization of brain activity. [33]
In Alzheimer's disease, MRI scans of the entire brain can accurately assess the rate of hippocampal atrophy, [38] [39] while PET scans can measure the brain's metabolic activity by measuring regional glucose metabolism, [33] and beta-amyloid plaques using tracers such as Pittsburgh compound B (PiB).
CT_of_a_normal_brain,_sagittal_22.png (770 × 430 pixels, file size: 168 KB, MIME type: image/png) This is a file from the Wikimedia Commons . Information from its description page there is shown below.
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PET scans showed that the compound was retained in areas of the cerebral cortex known to contain significant amyloid deposits from post-mortem examinations. The initial human study of PiB was expanded to include 16 Alzheimer's disease subjects and 9 cognitively normal controls, the report of which was published in 2004 in the Annals of ...