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Cetuximab, sold under the brand name Erbitux, is an epidermal growth factor receptor (EGFR) inhibitor medication used for the treatment of metastatic colorectal cancer and head and neck cancer. [2] Cetuximab is a chimeric (mouse/human) monoclonal antibody given by intravenous infusion .
Cetuximab (trade name: Erbitux ) is a recombinant chimeric monoclonal antibody designed to treat metastatic colorectal cancer and head and neck cancer. [14] In numerous cancers, the epidermal growth factor receptor (EGFR) is often inappropriately activated and overexpressed in cancer cells, leading to uncontrolled cell growth. [15]
In July 2009, the US Food and Drug Administration (FDA) updated the labels of two anti-EGFR monoclonal antibody drugs indicated for treatment of metastatic colorectal cancer, panitumumab (Vectibix) and cetuximab (Erbitux), to include information about KRAS mutations. [40]
Cetuximab target the epidermal growth factor receptor . It is approved for use in the treatment of metastatic colorectal cancer [25] [26] and squamous cell carcinoma of the head and neck. [27] [28] Panitumumab also targets the EGFR. It is approved for the use in the treatment of metastatic colorectal cancer. Bevacizumab targets circulating VEGF ...
Cetuximab [32] Erbitux: mab: chimeric: Epidermal growth factor receptor (EGFR) Y: metastatic colorectal cancer and head and neck cancer: Cibisatamab [5] mab: humanized: CEACAM5: cancer Cilgavimab [29] mab: human: spike protein receptor binding domain (RBD) of SARS-CoV-2: US emergency use authorization (EUA) when used with tixagevimab [48] COVID ...
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