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Palmitoylethanolamide (PEA) is an endogenous fatty acid amide, and lipid modulator. [2] A main target of PEA is proposed to be the peroxisome proliferator-activated receptor alpha (PPAR-α). [3] [4] PEA also has affinity to cannabinoid-like G-coupled receptors GPR55 and GPR119. [5]
General chemical structure of N-acylethanolamines. An N-acylethanolamine (NAE) is a type of fatty acid amide where one of several types of acyl groups is linked to the nitrogen atom of ethanolamine, and highly metabolic formed by intake of essential fatty acids through diet by 20:4, n-6 and 22:6, n-3 fatty acids, [1] [2] and when the body is physically and psychologically active,.
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Oleoylethanolamide (OEA) is an endogenous peroxisome proliferator-activated receptor alpha (PPAR-α) agonist.It is a naturally occurring ethanolamide lipid that regulates feeding and body weight in vertebrates ranging from mice to pythons.
Chemical structure of the ethanolamide anandamide. Ethanolamides are chemical compounds which are amides formed from carboxylic acids and ethanolamine.Some ethanolamides are naturally occurring, such as anandamide, palmitoylethanolamide and prostamides, which play physiological roles as lipid neurotransmitters and autacoids.
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