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Prevalence increases with age. The prevalence of nocturia in older men is about 78%. Older men have a higher incidence of LUTS than older women. [25] Around one third of men will develop urinary tract (outflow) symptoms, of which the principal underlying cause is benign prostatic hyperplasia. [26]
It affects about 2–6% of men. [3] Together with IC/BPS, it makes up urologic chronic pelvic pain syndrome (UCPPS). [4] The cause is unknown. [1] Diagnosis involves ruling out other potential causes of the symptoms such as bacterial prostatitis, benign prostatic hyperplasia, overactive bladder, and cancer. [2] [5]
The underlying mechanism involves the prostate pressing on the urethra thereby making it difficult to pass urine out of the bladder. [1] Diagnosis is typically based on symptoms and examination after ruling out other possible causes. [2] Treatment options include lifestyle changes, medications, a number of procedures, and surgery.
Bladder cancer is much more common in men than women; around 1.1% of men and 0.27% of women develop bladder cancer. [2] This makes bladder cancer the sixth most common cancer in men, and the seventeenth in women. [69] When women are diagnosed with bladder cancer, they tend to have more advanced disease and consequently a poorer prognosis. [69]
In the longer term, treatment depends on the cause. BPH may respond to alpha blocker and 5-alpha-reductase inhibitor therapy, or surgically with prostatectomy or transurethral resection of the prostate (TURP). [citation needed] Use of alpha-blockers can provide relief of urinary retention following de-catheterization for both men and women.
Recent studies [66] [68] have revealed that between 2.7 and 6.53 million women in the USA have symptoms of IC and up to 12% of women may have early symptoms of IC/BPS. Further study has estimated that the condition is far more prevalent in men than previously thought ranging from 1.8 to 4.2 million men having symptoms of interstitial cystitis.
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