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Syphilis (/ ˈ s ɪ f ə l ɪ s /) is a sexually transmitted infection caused by the bacterium Treponema pallidum subspecies pallidum. [1] The signs and symptoms depend on the stage it presents: primary, secondary, latent or tertiary.
By 1956, congenital syphilis had been almost eliminated, and female cases of acquired syphilis had been reduced to a hundredth of their level just 10 years previously. [ 90 ] In 1978 in England and Wales, homosexual men accounted for 58% of syphilis cases in (and 76% of cases in London), but by 1994–1996 this figure was 25%, possibly driven ...
Treponema pallidum, formerly known as Spirochaeta pallida, is a microaerophilic, gram-negative, spirochaete bacterium with subspecies that cause the diseases syphilis, bejel (also known as endemic syphilis), and yaws. [1] It is known to be transmitted only among humans and baboons. [2]
Tabes dorsalis is caused by demyelination by advanced syphilis infection (tertiary syphilis) when the primary infection by the causative spirochete bacterium, Treponema pallidum, is left untreated for an extended period of time (past the point of blood infection by the organism). [3]
Congenital syphilis is syphilis that occurs when a mother with untreated syphilis passes the infection to her baby during pregnancy or at birth. [4] It may present in the fetus, infant, or later. [1] [5] Clinical features vary and differ between early onset, that is presentation before 2-years of age, and late onset, presentation after age 2 ...
Bejel, or endemic syphilis, is a chronic skin and tissue disease caused by infection by the endemicum subspecies of the spirochete Treponema pallidum. Bejel is one of the "endemic treponematoses" ( endemic infections caused by spiral-shaped bacteria called treponemes ), a group that also includes yaws and pinta .
Syphilis was the disease most commonly targeted by premarital examination laws. Syphilis was relatively widespread in the first half of the twentieth century, estimated to affect more than 10% of Americans during their lifetime, with many of those afflicted unaware that they were carrying the disease. [ 3 ]
In 2016, there were 27,814 reported cases of syphilis, primary and secondary, in the United States, a 17.6% increase from the previous year and a 74% increase from the reported cases in 2012. [22] Primary and secondary syphilis have a high correlation to an HIV-coinfection, particularly in men who have sex with men (MSM).