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A painful and itchy reddish/purple patch of skin that occurs in the same location with repeated exposures to the causative drug is the classic presentation of a fixed drug reaction. The lips, genitals, and hands are often involved.
Some medications, like opioids and certain other drugs, induce urticaria by directly acting on mast cells, triggering histamine release. [2] Non-steroidal anti-inflammatory drugs (NSAIDs) contribute uniquely to urticaria by inhibiting the COX-1 pathway, leading to increased production of leukotrienes , vasodilators implicated in edema and ...
Another class of medications known to occasionally cause itching is known as serotonin reuptake inhibitors. [3] Itching is one of the most frequent adverse effects of opioid therapy. [4] A common artificial colloid used in clinical fluid management is hydroxyethyl starch (HES).
Medications for symptom relief – e.g., antihistamines for itching; paracetamol or NSAIDs for pain [2] Cold compress application [2] For severe reactions, discontinuation of the medication and acute medical treatment of the reaction may be required. [2]
The symptoms of DRESS syndrome usually begin 2 to 6 weeks but uncommonly up to 8–16 weeks after exposure to an offending drug. Symptoms generally include fever, an often itchy rash which may be morbilliform or consist mainly of macules or plaques, facial edema (i.e. swelling, which is a hallmark of the disease), enlarged and sometimes painful lymph nodes, and other symptoms due to ...
No definitive medical test is known for aquagenic pruritus. Rather, diagnosis is made by excluding all other possible causes of the patient's itching, including polycythemia vera. Since pruritus is a symptom of many serious diseases, it is important to rule out other causes before making a final diagnosis. [11]
EDS can be a symptom of a number of factors and disorders. Specialists in sleep medicine are trained to diagnose them. Some are: Insufficient quality or quantity of night time sleep [5] Obstructive sleep apnea [6] Misalignments of the body's circadian pacemaker with the environment (e.g., jet lag, shift work, or other circadian rhythm sleep ...
Oral medications are viewed as a second-line of treatment for pityriasis versicolor in the event of widespread, severe, recalcitrant or recurrent cases. Systemic therapies include itraconazole (200 mg daily for seven days) and fluconazole (150 to 300 mg weekly dose for 2 to 4 weeks) that are preferred to oral ketoconazole which is no longer ...