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22227 Ensembl ENSG00000109424 ENSMUSG00000031710 UniProt P25874 P12242 RefSeq (mRNA) NM_021833 NM_009463 RefSeq (protein) NP_068605 NP_033489 Location (UCSC) Chr 4: 140.56 – 140.57 Mb Chr 8: 84.02 – 84.03 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Thermogenin (called uncoupling protein by its discoverers and now known as uncoupling protein 1, or UCP1) is a mitochondrial ...
Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate, or uncouple, oxidative phosphorylation from ATP synthesis by dissipating the mitochondrial membrane potential as heat, also referred to as the mitochondrial proton leak.
2,4-Dinitrophenol (2,4-DNP or simply DNP) is an organic compound with the formula HOC 6 H 3 (NO 2) 2. It has been used in explosives manufacturing and as a pesticide and herbicide. In humans, DNP causes dose-dependent mitochondrial uncoupling , causing the rapid loss of ATP as heat and leading to uncontrolled hyperthermia —up to 44 °C (111 ...
In practice the efficiency may be even lower because the inner membrane of the mitochondria is slightly leaky to protons. [11] Other factors may also dissipate the proton gradient creating an apparently leaky mitochondria. An uncoupling protein known as thermogenin is expressed in some cell types and is a channel that can transport protons.
Neurosurgeon Dr. Paul Saphier, M.D., shared some ingredients to a healthy breakfast for heart and brain health, including yogurt, fruit and seeds, in a video posted to X.
A second contributing factor is that cristae, the inner membranes of mitochondria, increase the surface area and therefore the amount of proteins in the membrane that assist in the synthesis of ATP. Along the electron transport chain, there are separate compartments, each with their own concentration gradient of H + ions, which are the power ...
These foods and drinks are generally accepted as natural appetite suppressants. Green Tea Green tea contains compounds like catechins , which may help regulate hunger and boost metabolism, Keatley ...
The Mediterranean diet and variations of it, which emphasize intake of fruits, vegetables, whole grains and olive oil, while limiting meat, dairy and ultra processed foods, may be particularly ...