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As of 2023, PBMs managed pharmacy benefits for 275 million Americans and the three largest PBMs in the US, CVS Caremark, Cigna Express Scripts, and UnitedHealth Group’s Optum Rx, make up about 80% of the market share covering about 270 million people [4] [5] with a market of almost $600 billion in 2024.
The number of people with depression has reached new highs—and so has antidepressant use. As Americans are increasingly reaching for pharmaceutical solutions for depression—about one in eight ...
Antidepressants could increase the risk of suicidal thoughts and behavior in people with depression under the age of 25. In 2004, the U.S. Food and Drug Administration along with the Neuro-Psychopharmacologic Advisory Committee and the Anti-Infective Drugs Advisory Committee, concluded that there was a causal link between newer antidepressants and pediatric suicidality. [7]
Approximately 15–50% of people who suddenly stop an antidepressant develop antidepressant discontinuation syndrome. [7] [2] [3] [4] The condition is generally not serious, [2] though about half of people with symptoms describe them as severe. [4] Many restart antidepressants due to the severity of the symptoms. [4]
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Some people who are diagnosed with treatment-resistant depression may have an underlying undiagnosed health condition that is causing or contributing to their depression. Endocrine disorders like hypothyroidism , Cushing's disease , and Addison's disease are among the most commonly identified as contributing to depression .
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