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A lung biopsy is an interventional procedure performed to diagnose lung pathology by obtaining a small piece of lung which is examined under a microscope. [ 1 ] [ 2 ] Beyond microscopic examination for cellular morphology and architecture, special stains and cultures can be performed on the tissue obtained.
An incisional biopsy or core biopsy samples a portion of the abnormal tissue without attempting to remove the entire lesion or tumor. When a sample of tissue or fluid is removed with a needle in such a way that cells are removed without preserving the histological architecture of the tissue cells, the procedure is called a needle aspiration biopsy.
Fine-needle aspiration biopsies are very safe minor surgical procedures. Often, a major surgical (excisional or open) biopsy can be avoided by performing a needle aspiration biopsy instead, eliminating the need for hospitalization. In 1981, the first fine-needle aspiration biopsy in the United States was done at Maimonides Medical Center. [1]
Biopsy: Done by obtaining a piece of tissue from the tumor, classically done through bronchoscopy or CT guided needle biopsy, to study the histology of the tissue and confirm diagnosis. [ 1 ] Classification
Histopathologic image of small-cell carcinoma of the lung. CT-guided core needle biopsy. H&E stain. Small-cell carcinoma is an undifferentiated neoplasm composed of primitive-appearing cells. As the name implies, the cells in small-cell carcinomas are smaller than normal cells, and barely have room for any cytoplasm.
For cases suspicious enough to proceed to biopsy, small biopsies can be obtained by fine needle aspiration or bronchoscopy are commonly used for diagnosis of lung nodules. [19] CT guided percutaneous transthoracic needle biopsies have also proven to be very helpful in the diagnosis of SPN. [6]
used for fine needle aspiration of material from inside the body; used for diagnostic examinations of the cells hence obtained; video link: Trephine biopsy needle [4] used for taking a biopsy from a deep hard tissue like bone marrow (within a hard bone) Spirometer: used to test lung function; video link •Water-seal type-do- •Douglas bag ...
Biopsy can be accomplished via bronchoscopy, transthoracic needle biopsy, and video-assisted thorascopic surgery (VATS). [ 4 ] While sputum cytology has been shown to have limited utility, thoracentesis , or aspiration of pleural fluid with an ultrasound -guided needle, should be performed when pleural effusion is present.