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Cosibelimab, sold under the brand name Unloxcyt, is a monoclonal antibody used for the treatment of cutaneous squamous-cell carcinoma. [1] It is a programmed death ligand-1 (PD-L1) blocking antibody.
He is a true translational investigator, since he used these monoclonal antibodies to classify human B-cell leukemia and lymphomas as well as to create therapeutic agents for patients. . . More importantly, he was the first in the world to administer a monoclonal antibody to a human (a patient with B-cell lymphoma)." [11]
It is a fusion protein that combines a CD20 monoclonal antibody with the CD47 binding domain of SIRPα, allowing it to simultaneously engage both CD20 and CD47 on cancer cells. [1] Amulirafusp alfa has a dual mechanism of action that enhances both macrophage-mediated phagocytosis and natural killer cell activation. [2]
Humanized monoclonal antibodies are identified with the suffix "-zumab". They mostly originate from a human but differ in the component that attaches to its target. [7] An example of a humanized monoclonal antibody is crizanlizumab, which treats sickle cell disease. [6] Human monoclonal antibodies are identified with the suffix "-umab".
Antibody-directed enzyme prodrug therapy (ADEPT) involves the application of cancer-associated monoclonal antibodies that are linked to a drug-activating enzyme. Systemic administration of a non-toxic agent results in the antibody's conversion to a toxic drug, resulting in a cytotoxic effect that can be targeted at malignant cells.
Batoclimab (also known as HBM9161 or HL161) is a fully human monoclonal antibody administered by subcutaneous injection. It works by inhibiting the neonatal fragment crystallizable receptor, which leads to a reduction in antibodies of the thyrotropin receptor. It is being developed to treat myasthenia gravis and thyroid eye disease. [1] [2] [3]
While COVID-19 lands more people in hospitals, doctors are turning to monoclonal antibodies to help keep people out. Governor Greg Abbott was one of the latest political leaders to test positive ...
Sugemalimab, sold under the brand name Cejemly among others, is a monoclonal antibody used for the treatment of metastatic non-small cell lung cancer (NSCLC) in combination with chemotherapy. [1] It is an antineoplastic monoclonal antibody that potentiates T-cell responses, including anti-tumor responses, through blockade of PD-1 binding to PD ...