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Herpes simplex virions. Herpes simplex virus 1 and 2 (HSV 1 and HSV 2) are part of the alpha subfamily of herpesviruses. The lytic phase of infection occurs within mucoepithelial cells while the latent infection of these cells occurs in neurons. These two viruses are the cause of oral and genital herpes. [4]
HHV Latency Associated Transcript (HHV LAT) is a length of RNA which accumulates in cells hosting long-term, or latent, Human Herpes Virus (HHV) infections. The LAT RNA is produced by genetic transcription from a certain region of the viral DNA.
An example of such a gene product is the latency associated transcripts (LAT) in herpes simplex virus, which interfere with apoptosis by downregulating a number of host factors, including major histocompatibility complex (MHC) and inhibiting the apoptotic pathway. [17] A certain type of latency could be ascribed to the endogenous retroviruses.
Similar to other herpesviridae, the herpes simplex viruses establish latent lifelong infection, and thus cannot be eradicated from the body with current treatments. [ 63 ] Treatment usually involves general-purpose antiviral drugs that interfere with viral replication, reduce the physical severity of outbreak-associated lesions, and lower the ...
Site of Latency Means of Spread HHV‑1: Herpes simplex virus-1 (HSV-1) α (Alpha) Mucoepithelial: Oral and/or genital herpes, herpetic gingivostomatitis, pharyngitis, eczema herpeticum, herpetic whitlow, herpes simplex keratitis, erythema multiforme, encephalitis, as well as other herpes simplex infections: Neuron (sensory ganglia)
For HHV-6, latency is believed to occur exclusively through the integration of viral telomeric repeats into human subtelomeric regions. [20] Only one other virus, Marek's disease virus, is known to achieve latency in this fashion. [7]
Shemesh is the senior author of a new study recently published in the journal Cell Reports that identified a potential link between Alzheimer’s disease and the herpes simplex virus-1 (HSV-1).
HSV epigenetics is the epigenetic modification of herpes simplex virus (HSV) genetic code.. As of 2012, an estimated 3.7 billion people globally were infected with oral herpes simplex virus (HSV-1), and 417 million were living with genital herpes (HSV-2) worldwide (World Health Organization, 2018).