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In the United States, 20% of the population will be older than 65 years of age by the year 2030. Those 85 years and older will be the most rapidly growing group. [1] This is compounded by the fact that the majority of cancer patients will be in this age group. Age in itself is one of the most important risk factors for developing cancer.
Recently, there has been a change in cancer treatment toward less toxic, more customized regimens. Metronomic chemotherapy, which involves regularly giving patients low dosages of chemotherapy drugs, is one instance of this. [46] This technique has been shown to have the potential to change the tumor microenvironment and limit tumor growth. [47]
The systems of the body most affected by chemotherapy drugs include visual and semantic memory, attention and motor coordination and executive functioning. [9] [10] These effects can impair a chemotherapy patient's ability to understand and make decisions regarding treatment, perform in school or employment and can reduce quality of life. [10]
Chemotherapy is one of the major categories of the medical discipline specifically devoted to pharmacotherapy for cancer, which is called medical oncology. [1] [2] The term chemotherapy now means the non-specific use of intracellular poisons to inhibit mitosis (cell division) or to induce DNA damage (so that DNA repair can augment chemotherapy ...
CIPN afflicts between 30% and 40% of patients undergoing chemotherapy. Antineoplastic agents in chemotherapy are designed to eliminate rapidly dividing cancer cells, but they can also damage healthy structures, including the peripheral nervous system. [1] CIPN involves various symptoms such as tingling, pain, and numbness in the hands and feet. [2]
Researchers say chronic inflammation raises a person’s risk of developing colorectal cancer as well as suppresses the body’s ability to fight the disease. The Western diet, which is high in ...
Using vinorelbine as a regimen was shown to be feasible for very elderly patients who tend to have multiple comorbidities which is a condition that a patient has more than two diseases at a time, and require multiple medications [20] but, the effect of metronomic therapy is not only limited to aged patients. Etoposide may also be effective in ...
R-miniCHOP is indicated in elderly patients (>80 years) with diffuse large B-cell lymphoma due to less toxicity from the reduced dose in comparison to R-CHOP. R-Maxi-CHOP is used in mantle cell lymphoma and is given in 21-day intervals, alternating with R-HDAC (rituximab + high-dose cytarabine).