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Phossy jaw, formally known as phosphorus necrosis of the jaw, was an occupational disease affecting those who worked with white phosphorus (also known as yellow phosphorus) without proper safeguards. It is also likely to occur as the result of use of chemical weapons that contain white phosphorus.
Osteonecrosis of the jaw (ONJ) is a severe bone disease (osteonecrosis) that affects the jaws (the maxilla and the mandible). Various forms of ONJ have been described since 1861, and a number of causes have been suggested in the literature.
It is toxic, causing severe liver damage on ingestion and phossy jaw from chronic ingestion or inhalation. The odour of combustion of this form has a characteristic garlic odor, and samples are commonly coated with white " diphosphorus pentoxide ", which consists of P 4 O 10 tetrahedra with oxygen inserted between the phosphorus atoms and at ...
Although the methods of action are not yet completely understood, it is hypothesized that medication-associated osteonecrosis of the jaw is related to a defect in jaw bone healing and remodelling. The inhibition of osteoclast differentiation and function, precipitated by drug therapy, leads to decreased bone resorption and remodelling.
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Phossy jaw developed by inhalation of phosphorus vapour—particularly when the ingredient was heated—which caused osteonecrosis of the jaw bone. [13] This manifested itself in, initially, toothaches and flu-like symptoms, then tooth loss, abscesses, swelling of the gums, the formation of fistula and necrosis of the jaw. [14]
Radium jaw, or radium necrosis, is a historic occupational disease brought on by the ingestion and subsequent absorption of radium into the bones of radium dial painters. [ 1 ] [ 2 ] It also affected those consuming radium-laden patent medicines .
Bryant and May was involved in three of the most divisive industrial episodes of the nineteenth century, the sweating of domestic out-workers, the wage "fines" that led to the London matchgirls strike of 1888 and the scandal of "phossy jaw". The strike won important improvements in working conditions and pay for the mostly female workforce ...