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Features sine qua non for the diagnosis of follicular carcinoma are capsular invasion and vascular invasion by tumor cells. Still, focuses of the capsular invasion should be carefully evaluated and discriminated from the capsular rupture due to FNA penetration resulting in WHAFFT ( worrisome histologic alterations following FNA of thyroid ).
A Hürthle cell is larger than a follicular cell, and polygonal with distinct cell borders. [2] Key features of these oncocytic cells include a granular cytoplasm that stains eosinophilic (pink on H&E stain), which is commonly due to the oncocytes' high content of mitochondria, and a vesicular nucleus with a large nucleolus. [6]
Thyroid neoplasm is a neoplasm or tumor of the thyroid.It can be a benign tumor such as thyroid adenoma, [1] or it can be a malignant neoplasm (thyroid cancer), such as papillary, follicular, medullary or anaplastic thyroid cancer. [2]
Relative incidences of malignant thyroid tumors, with Hürthle cell carcinoma near top right. Hürthle cell neoplasm is a rare tumor of the thyroid, typically seen in women between the ages of 70 and 80 years old. When benign, it is called a Hürthle cell adenoma, and when malignant it is called a Hürthle cell carcinoma.
Follicular thyroid cancer (10 to 20% of cases [34]) – occasionally seen in people with Cowden syndrome. Some include Hürthle cell carcinoma as a variant and others list it as a separate type. [4] [36] Medullary thyroid cancer (5 [34] to 8% of cases) – cancer of the parafollicular cells, often part of multiple endocrine neoplasia type 2. [37]
Hurthle cell carcinoma, a variant of follicular thyroid carcinoma. Oncocytoma , a tumour composed of oncocytes, may be found as a less common salivary gland neoplasm also known as oxyphilic adenoma. Renal oncocytoma , a kidney tumour composed of oncocytes.
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