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Hurthle cell thyroid cancer is often considered a variant of follicular cell carcinoma. [3] [4] Hurthle cell forms are more likely than follicular carcinomas to be bilateral and multifocal and to metastasize to lymph nodes. Like follicular carcinoma, unilateral hemithyroidectomy is performed for non-invasive disease, and total thyroidectomy for ...
While Hurthle cells can occur in healthy thyroid glands, [1] they are often associated with Hashimoto's thyroiditis [4] and Graves' disease. [2] Hürthle cell neoplasms can be separated into Hürthle cell adenomas (benign tumours) and carcinomas (malignant tumours) [5] arising from the follicular epithelium of the thyroid gland. [6]
The tumor is often detected by imaging such as ultrasound. The location and size of the tumor may cause pressure and pain to the patient. But often the tumor goes undetected. After detection, the mass is tested using an invasive fine-needle aspiration biopsy. [5] Hürthle cell adenoma is the benign analogue of Hürthle cell carcinoma.
Hyalinizing trabecular tumor (d–f) is composed of trabeculae of elongated or polygonal cells admixed with abundant amounts of hyaline material negative for amyloid and positive for type IV collagen (f); Ki-67 is characteristically expressed in the cell membrane but not in the nuclei of the tumor cells (e). Follicular adenoma with signet ring ...
Squamous cell thyroid carcinoma; Sarcoma of thyroid; Hürthle cell carcinoma; The follicular and papillary types together can be classified as "differentiated thyroid cancer". [39] These types have a more favorable prognosis than the medullary and undifferentiated types. [40]
Histopathology of NIFTP, H&E stain. [1]Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) is an indolent thyroid tumor that was previously classified as an encapsulated follicular variant of papillary thyroid carcinoma, [2] necessitating a new classification as it was recognized that encapsulated tumors without invasion have an indolent behavior, [2] and may ...
Presence of small cells with round nuclei and scant cytoplasm with a diffuse solid pattern; Round or oval nests (insulae) or in trabeculae. Solid growth and presence of microfollicles, some of which contain dense colloid. Extrathyroidal extension and blood vessel invasion; Foci of necrosis, Larger than 5 cm in greatest diameter at diagnosis
Hurthle cell carcinoma, a variant of follicular thyroid carcinoma. Oncocytoma, a tumour composed of oncocytes, may be found as a less common salivary gland neoplasm also known as oxyphilic adenoma. Renal oncocytoma, a kidney tumour composed of oncocytes.