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Tacrolimus 0.1% Ointment As an ointment , tacrolimus is used in the treatment of dermatitis (eczema), in particular atopic dermatitis , if topical corticosteroids and moisturisers fail in helping. [ 17 ] [ 18 ] It suppresses inflammation in a similar way to steroids , and is equally as effective as a mid-potency steroid.
Pimecrolimus has a similar mode of action to that of tacrolimus but is more selective, with no effect on dendritic (Langerhans) cells. [19] It has lower permeation through the skin than topical steroids or topical tacrolimus [20] although they have not been compared with each other for their permeation ability through mucosa. In addition, in ...
Although it is a structural analogue of tacrolimus, it acts somewhat differently and has different side-effects. Contrary to ciclosporin and tacrolimus, drugs that affect the first phase of T lymphocyte activation, sirolimus affects the second phase, namely signal transduction and lymphocyte clonal proliferation.
Common side effects include allergic reactions, nausea, diarrhea, headache, trouble sleeping, and feeling tired. [1] It is not recommended in people with liver failure or porphyria. [1] Use during or in the months before pregnancy may result in harm to the baby. [1] [2] Griseofulvin works by interfering with fungal mitosis. [1]
There is no association to increased risk of cancer from topical use of pimecrolimus nor tacrolimus. [69] [71] When eczema is severe and does not respond to other forms of treatment, systemic immunosuppressants are sometimes used. Immunosuppressants can cause significant side effects and some require regular blood tests.
Potential risks: Some negative side effects like muscle cramps, facial swelling, and bloating have been reported in relation to medication interactions, as well as for some people with existing ...
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