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Systemic scleroderma, or systemic sclerosis, is an autoimmune rheumatic disease characterised by excessive production and accumulation of collagen, called fibrosis, in the skin and internal organs and by injuries to small arteries. There are two major subgroups of systemic sclerosis based on the extent of skin involvement: limited and diffuse.
Scleroderma is a group of autoimmune diseases that may result in changes to the skin, blood vessels, muscles, and internal organs. [2][6][8] The disease can be either localized to the skin or involve other organs, as well. [2] Symptoms may include areas of thickened skin, stiffness, feeling tired, and poor blood flow to the fingers or toes with ...
Atorvastatin is a statin medication used to prevent cardiovascular disease in those at high risk and to treat abnormal lipid levels. [4] For the prevention of cardiovascular disease, statins are a first-line treatment. [4] It is taken by mouth.
Research shows that statins may benefit those over the age of 70, too. BSIP/Getty Images. Statins are a type of medication that can help lower a person’s “bad” cholesterol, helping reduce ...
[15] [16] Acrosclerosis, also known as sclerodactyly, can develop with or without proximal scleroderma and is usually a later symptom of the condition. [10] Rashes are found in 50-60% of patients. [10] Common symptoms include photosensitivity and malar rashes, similar to those seen with SLE. [17] Discoid lesions are also occasionally seen. [10]
Muscle and other symptoms often cause patients to stop taking a statin. [87] This is known as statin intolerance. A 2021 double-blind multiple crossover randomized controlled trial (RCT) in statin-intolerant patients found that adverse effects, including muscle pain, were similar between atorvastatin and placebo. [ 88 ]
A heart attack occurs when blood flow to the heart becomes blocked. The most common cause is atherosclerosis, but other conditions like a blood clot, spasm, or tear in your coronary arteries can ...
Scleromyositis, is an autoimmune disease (a disease in which the immune system attacks the body). People with scleromyositis have symptoms of both systemic scleroderma and either polymyositis or dermatomyositis, and is therefore considered an overlap syndrome. Although it is a rare disease, it is one of the more common overlap syndromes seen in ...