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The most common combination of agents used in tumescent anesthesia is lidocaine (0.05-0.10%) and epinephrine (1 ppm). [3] [4] [5] For lidocaine, total doses of 35 mg/kg [6] and 55 mg/kg [7] have been reported as reasonably safe high-end doses, in the context of liposuction.
Lidocaine is an antiarrhythmic medication of the class Ib type. [7] This means it works by blocking sodium channels thus decreasing the rate of contractions of the heart. [10] [7] When injected near nerves, the nerves cannot conduct signals to or from the brain. [8] Lidocaine was discovered in 1946 and went on sale in 1948. [11]
A high dose of local anesthetic, typically lidocaine or prilocaine without adrenaline, [6] is slowly injected as distally as possible into the exsanguinated limb. The veins are filled with the anesthetic, with the anesthetic setting into local tissue after approximately 6–8 minutes, after which the surgery, reduction , or manipulation of the ...
Lidocaine, the drug the CDC namechecks in its updated guidelines, is the most widely studied and commonly used local anesthetic for IUD insertions. It can be applied topically as a gel, ...
High flow rates are attainable with an IO infusion, up to 125 milliliters per minute. This high rate of flow is achieved using a pressure bag to administer the infusion directly into the bone. Large volume IO infusions are known to be painful. 1% lidocaine is used to ease the pain associated with large volume IO infusions in conscious people. [3]
Many local anesthetics fall into two general chemical classes, amino esters (top) and amino amides (bottom). A local anesthetic (LA) is a medication that causes absence of all sensation (including pain) in a specific body part without loss of consciousness, [1] providing local anesthesia, as opposed to a general anesthetic, which eliminates all sensation in the entire body and causes ...
Propofol, a drug with similar effects to Sodium Pentathol, is often used through intravenous infusion through an IV during general anesthesia after gasses are initiated. Morphine is often used to control pain during the dental surgery under general anesthesia. The morphine is usually administered through IV.
Today, I still receive regular infusion treatments to keep Gaucher symptoms at bay, and I will need this medication for the rest of my life (though some researchers are looking into running ...