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Deuterated chloroform, also known as chloroform-d, is the organic compound with the formula CDCl 3. Deuterated chloroform is a common solvent used in NMR spectroscopy. [2] The properties of CDCl 3 and ordinary CHCl 3 are virtually identical. Deuterochloroform was first made in 1935 during the years of research on deuterium. [3]
Deuterated chloroform. Deuterated solvents are a group of compounds where one or more hydrogen atoms are substituted by deuterium atoms. These isotopologues of common solvents are often used in nuclear magnetic resonance spectroscopy. [1]
Singly substituted isotopologues may be used for nuclear magnetic resonance experiments, where deuterated solvents such as deuterated chloroform (CDCl 3 or C 2 HCl 3) do not interfere with the solutes' 1 H signals, and in investigations of the kinetic isotope effect.
The following compounds are liquid at room temperature and are completely miscible with water; they are often used as solvents. Many of them are hygroscopic.
Deuterated chloroform is an isotopologue of chloroform with a single deuterium atom. CDCl 3 is a common solvent used in NMR spectroscopy. Deuterochloroform is produced by the reaction of hexachloroacetone with heavy water. [31] The haloform process is now obsolete for production of ordinary chloroform.
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Deuterated (deuterium = 2 H, often symbolized as D) solvents especially for use in NMR are preferred, e.g. deuterated water, D 2 O, deuterated acetone, (CD 3) 2 CO, deuterated methanol, CD 3 OD, deuterated dimethyl sulfoxide, (CD 3) 2 SO, and deuterated chloroform, CDCl 3. However, a solvent without hydrogen, such as carbon tetrachloride, CCl 4 ...
A variant of this reaction is used to manufacture deuterated chloroform, in reaction of hexachloroacetone with heavy water catalysed by base: [5] [6] O=C(CCl 3) 2 + D 2 O → 2 CDCl 3 + CO 2. Further variant uses decomposition of calcium trichloroacetate in heavy water: [7] Ca(CCl 3 CO 2) 2 + D 2 O → 2 CDCl 3 + CaCO 3 + CO 2