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Diabetic ketoacidosis (DKA) is characterized by uncontrolled hyperglycemia, metabolic acidosis, and increased body ketone concentration. It is a life-threatening complication of diabetes and is usually seen in patients with type-1 diabetes mellitus.
Pathophysiology of DKA. Insulin deficiency and an increase in counterregulatory hormones (glucagon, catecholamines, cortisol) causes the body to metabolize triglycerides and amino acids instead of glucose for energy. Serum levels of glycerol and free fatty acids rise because of unrestrained lipolysis.
PATHOPHYSIOLOGY. Insulin deficiency, increased insulin counter-regulatory hormones (cortisol, glucagon, growth hormone, and catecholamines) and peripheral insulin resistance lead to hyperglycemia, dehydration, ketosis, and electrolyte imbalance which underlie the pathophysiology of DKA.
Diabetic Ketoacidosis (DKA) August 6, 2021 by Josh Farkas. CONTENTS. Rapid Reference. Getting started. Evaluating anion gap & ketoacidosis. Definition & severity of DKA. Evaluating the cause of DKA. Core components of DKA resuscitation. Fluid administration. Electrolyte management. Insulin infusion. Long-acting, basal insulin.
The objective of this consensus report is to provide up-to-date knowledge about the epidemiology, pathophysiology, clinical presentation, and recommendations for the diagnosis, treatment, and prevention of diabetic ketoacidosis (DKA) and hyperglycemic hyperosmolar state (HHS) in adults.
Diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemic state (HHS) represent two extremes in the spectrum of decompensated diabetes. DKA and HHS remain important causes of morbidity and mortality among diabetic patients despite well-developed diagnostic criteria and treatment protocols (1).
Diabetic ketoacidosis (DKA) is an acute, major, life-threatening complication of diabetes characterized by hyperglycemia, ketoacidosis, and ketonuria.
This Primer by Umpierrez and colleagues reviews the epidemiology, pathophysiology, diagnosis and management of diabetic ketoacidosis, the most common acute hyperglycaemic emergency in people...
Diabetes-related ketoacidosis (DKA) happens when you have a lack of insulin in your body. It’s a life-threatening complication of diabetes and undiagnosed Type 1 diabetes. It’s important to familiarize yourself with the early signs and triggers of DKA so you can get medical help as soon as possible. Diabetes Care.
Pathophysiology of diabetic ketoacidosis. In the usual clinical situation, a rise in counterregula-tory hormones contributes to accelerated gluconeogen - esis, glycogenolysis, and impaired glucose utilization by peripheral tissues and leads to diabetic ketoacidosis. 25. Glucagon is the primary counterregulatory hormone