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The [18 F]FDG-6-phosphate formed when [18 F]FDG enters the cell cannot exit the cell before radioactive decay. As a result, the distribution of [18 F]FDG is a good reflection of the distribution of glucose uptake and phosphorylation by cells in the body. [citation needed] The fluorine in [18 F]FDG decays radioactively via beta-decay to 18 O −.
Fluorine-18 (18 F, also called radiofluorine) is a fluorine radioisotope which is an important source of positrons. It has a mass of 18.0009380(6) u and its half-life is 109.771(20) minutes. It decays by positron emission 96.7% of the time and electron capture 3.3% of the time. Both modes of decay yield stable oxygen-18.
Whole-body PET scan using 18 F-FDG (fluorodeoxyglucose). The normal brain and kidneys are labeled, and radioactive urine from breakdown of the FDG is seen in the bladder. In addition, a large metastatic tumor mass from colon cancer is seen in the liver. PET scanning with the radiotracer [18 F]fluorodeoxyglucose (FDG) is widely used in clinical ...
3-dimensional [18 F]FDG-PET image with 3D ROI generated by a threshold based algorithm.The blue dot in the MIP image bottom right marks the maximum SUV within the ROI.. The standardized uptake value (SUV) is a nuclear medicine term, used in positron emission tomography (PET) as well as in modern calibrated single photon emission tomography (SPECT) imaging for a semiquantitative analysis. [1]
Gallium scan showing panda (A) and lambda (B) patterns, considered specific for sarcoidosis in the absence of histological confirmation. In the past, the gallium scan was the gold standard for lymphoma staging, until it was replaced by positron emission tomography (PET) using 18 F-fluorodeoxyglucose (FDG).
DOTA linked to the monoclonal antibody tacatuzumab and chelating yttrium-90 Whole-body PET scan using 18 F-FDG showing intestinal tumors and non-specific accumulation in bladder Radiolabeling is a technique used to track the passage of a molecule that incorporates a radioisotope through a reaction, metabolic pathway, cell, tissue, organism, or ...
One such radiopharmaceutical is 2-deoxy-2-(18 F)fluoro-D-glucose (generically referred to as fludeoxyglucose), commonly abbreviated as 18 F-FDG, or simply FDG. [22] In PET imaging, FDG can be used for assessing glucose metabolism in the brain and for imaging cancer tumors.
Imaging with fluorine-18 fluorodeoxyglucose (FDG) PET may be valuable to image some neuroendocrine tumors. [66] This scan is performed by injected radioactive sugar intravenously. Tumors that grow more quickly use more sugar. Using this scan, the aggressiveness of the tumor can be assessed.