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The health effects associated with organophosphate poisoning are a result of excess acetylcholine (ACh) present at different nerve synapses and neuromuscular junctions across the body. Specifically, acetylcholinesterase (AChE), the enzyme that normally and constantly breaks down acetylcholine, is inhibited by the organophosphate substance.
The formation of organophosphates is an important part of biochemistry and living systems achieve this using a variety of enzymes. Phosphorylation is essential to the processes of both anaerobic and aerobic respiration, which involve the production of adenosine triphosphate (ATP), the "high-energy" exchange medium in the cell.
Furthermore, certain organophosphates can cause OPIDN, organophosphate-induced delayed polyneuropathy. This is a disease, which is characterized by degeneration of axons in the peripheral and central nervous system. This disease will show a few weeks after contamination with the organophosphate.
Organophosphate-induced delayed neuropathy (OPIDN), also called organophosphate-induced delayed polyneuropathy (OPIDP), is a neuropathy caused by killing of neurons in the central nervous system, especially in the spinal cord, as a result of acute or chronic organophosphate poisoning.
Health effects of pesticides may be acute or delayed in those who are exposed. [1] Acute effects can include pesticide poisoning, which may be a medical emergency. [2] Strong evidence exists for other, long-term negative health outcomes from pesticide exposure including birth defects, fetal death, [3] neurodevelopmental disorder, [4] cancer, and neurologic illness including Parkinson's disease ...
The first and most important step of metabolism of chlorfenvinphos in humans is accomplished by the enzyme cytochrome P450 in liver microsomes. This enzyme facilitates oxidative dealkylation of the compound to acetaldehyde and 2-chloro-1-(2,4-dichlorophenyl) vinylethylhydrogen phosphate, the latter of which quickly breaks down to acetophenone .
People are ingesting borax. Also known by its chemical name sodium borate decahydrate, borax is a salt typically used to kill ants and boost laundry detergent, among other household cleaning needs ...
Dichlofenthion is an organophosphate insecticide that has previously been used in various countries for agricultural purposes to control pests. The compound is still persistent in the environment today. Consequently, areas where agricultural practices involve the use of dichlofenthion may pose risks of exposure to humans.