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Likely due to increased activation of the estrogen and/or progesterone receptors, spironolactone has very weak but significant antigonadotropic effects. [ 13 ] [ 14 ] Spironolactone has a very short biological half-life and is considered to be a prodrug ; hence, its active metabolites are responsible for most of its pharmacodynamics.
[39] [64] [112] Aside from these adverse effects, the side effects of spironolactone in women taking high doses are minimal, and it is well tolerated. [64] [86] [113] A potential side effect of spironolactone is hyperkalemia (high potassium levels), which, in severe cases, can be life-threatening. [8]
This is a list of antiandrogens, [1] or drugs that prevent the effects of androgens like testosterone and dihydrotestosterone (DHT). [2] It includes direct antagonists of the androgen receptor (AR), androgen synthesis inhibitors like 5α-reductase inhibitors and CYP17A1 inhibitors , and antigonadotropins like GnRH analogues , estrogens , and ...
Spironolactone reduces the amount of androgen hormones in your body, which cuts down sebum production. Its effects on hormones are so pronounced that it is not recommended for treating acne in men ...
Spironolactone is a once-a-day tablet that can stop hair loss from progressing and encourage new hair growth. It’s especially useful for women with hormonal issues like PCOS. It may take six to ...
She typically recommends patients take a very low dose of spironolactone, an oral medication that can inhibit your body from converting estrogen into testosterone, which causes hormonal pimples.
Drospirenone is a progestin and antiandrogen medication which is used in birth control pills to prevent pregnancy and in menopausal hormone therapy, among other uses. [1] [10] It is available both alone under the brand name Slynd and in combination with an estrogen under the brand name Yasmin among others.
[12] [13] Due to its activity as an androgen receptor antagonist and progesterone receptor agonist, spironolactone causes adverse effects, including gynecomastia or decreased libido in males and menstrual abnormalities in females. [14] Spironolactone also causes hyperkalemia [15] and renal insufficiency. [16]