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Lipinski's rule of five, also known as Pfizer's rule of five or simply the rule of five (RO5), is a rule of thumb to evaluate druglikeness or determine if a chemical compound with a certain pharmacological or biological activity has chemical properties and physical properties that would likely make it an orally active drug in humans.
The Department of Veterans Affairs (VA) began to provide disability benefits for post-traumatic stress disorder (PTSD) in the 1980s after the diagnosis became part of official psychiatric nosology. Post-traumatic stress disorder (PTSD) is a serious, potentially debilitating psychiatric disorder that can develop after experiencing one or more ...
Christopher A. Lipinski is a medicinal chemist who is working at Pfizer, Inc. [1] He is known for his "rule of five" , an algorithm that predicts drug compounds that are likely to have oral activity. [ 1 ]
The VA offers several education and career readiness programs including tuition assistance, vocational training, and career counseling. [6] The Post-9/11 Veterans Educational Assistance Act of 2008 (commonly known as the "Post 9/11 GI Bill") provides full tuition and fees at four-year colleges or other qualified educational programs for Veterans who served on active duty for at least 3 years ...
From 1996 to 2012, under the trade name Lipitor, atorvastatin became the world's best-selling medication of all time, with more than $125 billion in sales over approximately 14.5 years. [ 119 ] and $13 billion a year at its peak, [ 120 ] Lipitor alone "provided up to a quarter of Pfizer Inc.'s annual revenue for years."
At least two Pfizer drugs, Ibrance and Xtandi, could be on the 2027 list. U.S. patents for both cancer drugs expire that year and Pfizer executives have estimated a muted financial impact, while ...
The class is on the World Health Organization's List of Essential Medicines with simvastatin being the listed medicine. [10] In 2005, sales were estimated at US$18.7 billion in the United States. [11] The best-selling statin is atorvastatin, also known as Lipitor, which in 2003 became the best-selling pharmaceutical in history. [12]
Pfizer introduced Lipitor in 1997, and the drug drove more than $130 billion in sales during its first 14 years on the market. The pharma distributors claimed Pfizer fraudulently sought to extend ...