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Common side effects include headache, nausea, and vomiting. While use during pregnancy may harm the fetus, not using it in methemoglobinemia is likely more dangerous. [6] [2] Methylene blue was first prepared in 1876, by Heinrich Caro. [9] It is on the World Health Organization's List of Essential Medicines. [10]
Methylene blue is given as a 1% solution (10 mg/ml) 1 to 2 mg/kg administered intravenously slowly over five minutes. Although the response is usually rapid, the dose may be repeated in one hour if the level of methemoglobin is still high one hour after the initial infusion. Methylene blue inhibits monoamine oxidase, and serotonin toxicity can ...
Sulfonamides (such as sulfanilamide, sulfamethoxazole, and mafenide), thiazolesulfone, methylene blue, and naphthalene should also be avoided by people with G6PD deficiency as they antagonize folate synthesis, as should certain analgesics (such as phenazopyridine and acetanilide) and a few non-sulfa antibiotics (nalidixic acid, nitrofurantoin ...
The synthetic dye methylene blue, containing the structure, was described in 1876. Many water-soluble phenothiazine derivatives, such as methylene blue, methylene green, thionine, and others, can be electropolymerized into conductive polymers used as electrocatalysts for NADH oxidation in enzymatic biosensors and biofuel cells. [10] [11] [12]
Allergic-like reactions and methemoglobinemia have been documented after the use of methylene blue dye in chromopertubation. [9] These reported symptoms vary from blue discoloration of body fluids to anaphylactic shock. [10] Methemoglobinemia is a blood disorder that can potentially result in various levels of cyanosis. [11]
Pa is uninterested in a "cure", but Cussy Mary takes Doc's pills of methylene blue, which turns her skin white. However, the treatment is accompanied by side-effects of headaches and vomiting, and is very short-term.
A condition called chromhidrosis caused a woman's sweat to turn blue while she was pregnant. ... Lighter Side. Politics. Science & Tech. Sports. Weather. 24/7 Help. For premium support please call:
Methylenetetrahydrofolate reductase deficiency is the most common genetic cause of elevated serum levels of homocysteine (hyperhomocysteinemia).It is caused by genetic defects in MTHFR, which is an important enzyme in the methyl cycle.